Abstract
The black aspergilli constitute an important group of species, both for their use in the biotechnological industry, and since they account for some of the most widespread food and feed contaminants. Most recently we have characterized the full biosynthetic pathway of the antibiotic yanuthone D from the industrially workhorse Aspergillus niger.1 On top of that we have presented a method for sclerotium induction, whereby we have reported sclerotia formation for the first time in seven black aspergilli, including A. niger.2 Thorough investigation by UHPLC-DAD-HRMS of fungal extracts, with and without sclerotia formation, have revealed a highly regulated metabolic profile for a number of species. We present this as an approach for the discovery of novel secondary metabolites from otherwise silent pathways.
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