Abstract
In the relentless pursuit of conquering gastric cancer, researchers have uncovered a promising avenue: CagA, the captivating oncoprotein encoded by Helicobacter pylori (H. pylori). This review delves deep into the multifaceted role of CagA in the pathogenesis of gastric cancer, shedding light on its remarkable ability to manipulate signaling pathways and trigger the epithelial-mesenchymal transition (EMT) phenomenon, which underlies cancer invasion. By unraveling the mysteries of H. pylori’s influence on signaling pathways within gastric cells, this review presents cutting-edge insights into the pathogenesis of this devastating malignancy. Moreover, it unveils the fascinating relationship between H. pylori infection and extra-gastric diseases, offering a panoramic view of the broader impact of this microbe on human health Beyond the realm of basic science, this exploration of H. pylori’s dark secrets holds the promise of revolutionizing the realm of gastric cancer prevention, diagnosis, and treatment. With CagA as the spotlight, the stage is set for a transformative journey towards conquering this devastating malignancy and embracing a brighter future in cancer therapeutics.
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