Unmet Personal Patient Needs in Psoriasis Patients with Low Disease Activity on Adalimumab, Etanercept or Ustekinumab.

Abstract

BackgroundPersonal treatment goals have been systematically investigated in psoriasis patients with active but not in controlled disease.ObjectivesTo explore patient needs in psoriasis patients with controlled disease due to biologic therapy with adalimumab, etanercept or ustekinumab.MethodsTreatment needs in patients on adalimumab, etanercept or ustekinumab with a stable low disease activity for ≥ 6 months and preferably a Psoriasis Area and Severity Index (PASI) < 5, were explored with the Patient Needs Questionnaire (PNQ). Goal importance was expressed as overall mean importance score, percentage of patients that reported a goal to be quite/very important, and per PNQ subscale. Data were analysed separately for treatment, gender, age group (< 50 vs. ≥ 50 years), biologic naivety and willingness to participate in a pragmatic dose-reduction strategy.ResultsSixty-five patients were included. ‘To be free of itching’, ‘to be healed of all skin defects’ and ‘to have confidence in the therapy’ were rated quite/very important in 78.5% of the patients, followed by ‘to have no fear the disease will progress’ (75.4%) and ‘to get better skin quickly’ (75.4%). Goals related to the subscale ‘confidence in healing’ were still of high importance in controlled disease. Least importance was attributed towards social goals. For female patients, it was significantly more important than for males to ‘feel less depressed’ and ‘be comfortable showing yourself more in public’.ConclusionsPsoriasis patients with controlled disease still report substantial treatment needs, with high importance ascribed to confidence in healing. To apply personalized medicine, treatment needs should be explored on an individual level.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40801-021-00227-w.