Abstract
Extensive preclinical and clinical data accumulated over the last few decades have documented that host immunity can play paradoxical roles in both promoting tumor outgrowth and in promoting tumor control and sculpting the immunogenicity of tumors. T cells and, more specifically, CD8 T cells are considered to be essential for tumor killing, whereas the composition of the innate immune compartment serves to dictate T cell infiltration (secretion of chemokines), activation, phenotype, and functional capacity.
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