Abstract
Unmasking Adherence as a Cause of Unexplained Poor Growth Response in Adolescents Receiving Growth Hormone
Highlights
Treatment adherence in patients affected by chronic health conditions is a well-known issue, in the adolescent population [1,2,3,4]
We retrospectively evaluated adolescents with unexplained poor growth response to GH therapy who were transitioned to a digital record of growth hormone administration to determine if their poor growth response could be attributed to nonadherence
Baseline height standard deviation scores
Summary
Treatment adherence in patients affected by chronic health conditions is a well-known issue, in the adolescent population [1,2,3,4]. Low adherence to growth hormone (GH) therapy is a major cause of treatment failure, with nonadherence rates estimated to be as high as 82% [5,6,7,8,9,10]. Patient questioning and other methods of estimating GH adherence, such as prescription renewal rates, are not reliable ways of measuring medication adherence [1,4,5,9]. When questioned about adherence to GH therapy, many patients admit to ‘white coat adherence,’ in which patients follow their prescribed medication regimen only for a few days leading up to their appointment [1]. Adherence declines with duration of therapy, and adolescents have the lowest rates of GH adherence [1,8,9,15,16,17]
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