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Abstract
Recent genomics and epigenetic advances haveempowered the exploration of DNA/RNA methylation and histone modifications crucial for gene expression in response to stress, agingand disease. Interest in understanding neuronal plasticity's epigenetic mechanisms, influencing brain rewiring amid development, agingand neurodegenerative disorders, continues to grow. Histone acetylation dysregulation, a commonality in diverse brain disorders, hasbecomea therapeutic focus. Histone acetyltransferasesand histone deacetylases haveemerged as promising targets for neurodegenerative disorder treatment. This review delves into histone acetylation regulation, potential therapiesand future perspectives for disorders like Alzheimer's, Parkinson'sand Huntington's. Exploring genetic-environmental interplay through models and studies reveals molecular changes, behavioral insightsand early intervention possibilities targeting the epigenome in at-risk individuals.
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