Abstract
Adenosine (Ado) drives immune suppression in the tumor microenvironment. In this issue of Cancer Cell, Klysz etal. investigate Ado-mediated immunosuppression. Overexpression of Ado deaminase (ADA-OE), metabolizing Ado to inosine (INO), induces stemness and improves CAR Tcell functionality. Likewise, exposure to INO enhances CAR Tcells' function and induces stemness features.
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