Abstract
IT has been shown by Demerec, Hartman and others1, that in Escherichia coli and Salmonella typhimurium it is usual for loci controlling related functions to be closely situated to each other on the chromosome and even for the arrangement of such loci to be the same as the sequence of biosynthetic steps concerned. The chief exception to this rule is the arginine biosynthetic pathway in which the controlling loci are distributed widely over the E. coli chromosome2. Using the technique of joint transduction, we have obtained evidence that in Psendomonas aeruginosa this latter type of marker distribution of loci controlling sequential biosynthetic steps occurs with all the pathways so far investigated.
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