Abstract
We investigated the virucidal effects in solution of a new type of disinfectant, calcium bicarbonate mesoscopic crystals, designated CAC-717, against various types of virus. CAC-717 in solution is alkaline (pH 12.4) and has a self-electromotive force that generates pulsed electrical fields. Upon application to human skin, the pH of the solution becomes 8.4. CAC-717 contains no harmful chemicals and is thus non-irritating and harmless to humans and animals. Its virucidal effects were tested against six types of animal virus: enveloped double-strand (ds)-DNA viruses, non-enveloped ds-DNA viruses, non-enveloped single strand (ss)-DNA viruses, enveloped ss-RNA viruses, non-enveloped ss-RNA viruses, and non-enveloped ds-RNA viruses. The treatment resulted in a reduction in viral titer of at least 3.00 log10 to 6.38 log10. Fetal bovine serum was added as a representative organic substance. When its concentration was ≥20%, the virucidal effect of CAC-717 was reduced. Real-time PCR revealed that CAC-717 did not reduce the quantity of genomic DNA of most of the DNA viruses, but it greatly reduced that of the genomic RNA of most of the RNA viruses. CAC-717 may therefore be a useful biosafe disinfectant for use against a broad range of viruses.
Highlights
Received: 22 December 2021Control of microorganisms is essential in many fields, such as medicine, veterinary care, dentistry, food processing, and in the environmental protection
We evaluated the virucidal activity of CAC-717 against 22 viruses (Table 1) after various incubation times ranging from approximately 2 s to 60 min, with the viral solution at room temperature (Tables 2 and 3)
The virucidal effects are represented at the exponential difference between the viral titers of virus treated with maintenance medium and CAC-717
Summary
Control of microorganisms is essential in many fields, such as medicine, veterinary care, dentistry, food processing, and in the environmental protection. Disinfection of pathogens is typically conducted using chemical disinfectants such as aldehydes, iodine, chlorine phenolics, sodium carbonate, citric acid, and acetic acid [1–3]. There are various problems with the use of such disinfectants. Many disinfectants are corrosive or act as irritants, and they may leave a residue [4]. An ideal disinfectant would be broad-spectrum, non-toxic, non-irritating, noncorrosive, and effective for to humans, animals, and the environment. No such ideal disinfectant has yet been found
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