Abstract
Magnetic nanoparticles biofunctionalized with antibodies are useful for specifically labeling target biomolecules. By measuring magnetic signals after the association between biofunctionalized magnetic nanoparticles and target biomolecules, the concentration of target biomolecules can be quantitatively detected. One of measuring methodologies is so-called immunomagnetic reduction (IMR), in which the reduction in ac magnetic susceptibility of magnetic reagent is a function of the concentration of target biomolecules. In this letter, the relationship between the magnetic reduction signal of reagent and the concentration of target biomolecules is explored. According to the experimental results on various kinds of target biomolecules, such as proteins and chemicals, the magnetic reduction signal as a function of concentration of various target biomolecules can be scaled to a universal curve. This universal curve is a logistic function. This implies that there exists a unique mechanism for the association between the target biomolecules and biofunctionalized magnetic nanoparticles in an IMR assay.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
