Abstract
Development and application of physiologically detailed dynamic models of the action potential (AP) and Ca 2+ cycling in cardiac cells is a rapidly growing aspect of computational cardiac electrophysiology. Given the large scale of the nonlinear system involved, questions were recently raised regarding reproducibility, numerical stability, and uniqueness of model solutions, as well as ability of the model to simulate AP propagation in multicellular configurations. To address these issues, we reexamined ventricular models of myocyte AP developed in our laboratory with the following results. 1), Recognizing that the model involves a system of differential-algebraic equations, a procedure is developed for estimating consistent initial conditions that insure uniqueness and stability of the solution. 2), Model parameters that can be used to modify these initial conditions according to experimental values are identified. 3), A convergence criterion for steady-state solution is defined based on tracking the incremental contribution of each ion species to the membrane voltage. 4), Singularities in state variable formulations are removed analytically. 5), A biphasic current stimulus is implemented to completely eliminate stimulus artifact during long-term pacing over a broad range of frequencies. 6), Using the AP computed based on 1–5 above, an efficient scheme is developed for computing propagation in multicellular models.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.