Abstract
Classical selective homodecoupling was used in a 1H NMR purity assay to improve accuracy by overcoming spectral overlaps due to 1H-1H spin coupling. Dummy irradiation at a specific frequency was used in addition to irradiation at a 1H resonance of the analyte to avoid irradiation bias. The method was validated in a 1H NMR purity assay of high-purity diethyl phthalate (National Metrology Institute of Japan Certified Reference Material (NMIJ CRM), purity: 99.98%). The obtained purity value biases were 0.27% or less. The utility of the method was demonstrated in another 1H NMR purity assay of dipropyl phthalate (NMIJ CRM, purity: 98.41%), which contained a tiny amount of the structurally similar compound methyl propyl phthalate as an impurity. An accurate assay was achieved with the method, giving a purity of 98.39%, whereas the conventional method gave a purity 99.13%.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
