Unique presentation of occult breast cancer with uterine cervix metastasis.

Emanuela Cimpeanu,Nisha Lakhi,Gabrielle Tricorico,Maxim Shulimovich,Svetoslav Bardarov,Jibran Ahmed

doi:10.1002/ccr3.2306

Abstract

We are reporting a case of occult breast cancer (OBC) diagnosed via biopsy of an asymptomatic cervical mass. While non‐OBC has occasionally been reported as metastatic to the uterine cervix, OBC never has, to our knowledge. Awareness of this presentation can be beneficial for a more expedite diagnosis and treatment.

Highlights

In women in the United States, breast cancer represents the most common malignancy and the second leading cause of cancer‐related deaths.[1]
A diagnosis of metastatic breast cancer, either occult or nonoccult, can be considered in certain patients presenting with an asymptomatic cervical mass
The patient was referred for positron emission tomography‐computed tomography (PET‐ CT) (Figure 1A and B), which was significant for hypermetabolic activity in the cervix and uterus, skeletal metastatic disease, and right axillary adenopathy

Summary

| INTRODUCTION

In women in the United States, breast cancer represents the most common malignancy and the second leading cause of cancer‐related deaths.[1]. It is characterized by metastatic disease confirmed histologically as primary breast cancer, in the absence of a tumor mass on clinical examination and mammography.[3]. A diagnosis of metastatic breast cancer, either occult or nonoccult, can be considered in certain patients presenting with an asymptomatic cervical mass. The patient had bilateral breast ultrasound and mammogram, both of which did not identify any abnormalities She denied abdominal discomfort and vaginal discharge. The patient was referred for positron emission tomography‐computed tomography (PET‐ CT) (Figure 1A and B), which was significant for hypermetabolic activity in the cervix and uterus, skeletal metastatic disease, and right axillary adenopathy. CT‐guided biopsy of the right axillary lymph node showed infiltration of tumor cells, morphologically identical to the ones observed in the cervix, with Ki‐67 of 10%‐15%. The patient will be monitored with surveillance imaging and further clinical examinations

| DISCUSSION

| CONCLUSION

Findings

CONFLICT OF INTEREST