Abstract
Dysgerminoma of the ovary is a rare malignancy. It is common in dysegenetic ovaries. The prognosis is excellent if treated properly. This is a case report of a girl with agenesis of the uterus, streak ovary and dysgerminoma. Her external genitalia seemed normal. Ultrasonography indicated uterine agenesis and showed a solid mass on right gonad. The left gonad was streak ovary. There was minimal ascites and cytology was positive for malignant cell. Tumor markers were normal. Bilateral gonadectomy with removal of the tumor was performed. She received chemotherapy and was disease free at 2-year follow up. The combination of an ovarian dysgerminoma with uterine agenesis and streak ovary is a rare finding. Ovarian dysgerminoma is chemosensitive and potentially curable even when in advanced stage.
Highlights
Dysgerminoma can be associated with pure gonadal dysgenesis or peritoneal cytology was positive for malignant cell
This girl has a unique combination of an ovarian dysgerminoma in right ovary with uterine agenesis and her left ovary was abnormal.There is a high risk of neoplasm in dysgenetic gonads
Conservative surgical management is desirable for nulliparous women with unilateral dysgerminomas, the presence of 46, XY gonadal dysgenesis should be suspected in all premenarchal girls with ovarian germ cell malignancies
Summary
Dysgerminoma of the ovary is a rare malignancy. This is a case report of a girl with agenesis of the uterus, streak ovary and dysgerminoma. There was minimal ascites and cytology was positive for malignant cell. Dysgerminoma, the most common malignant ovarian germ cell tumor, is the Received: 15.02.2008 Provisionally accepted: 10.03.2008 ovarian counterpart of testicular seminoma and is derived from undifferentiated. Dysgerminoma can be associated with pure gonadal dysgenesis or peritoneal cytology was positive for malignant cell.
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