Abstract
The UniProt Knowledgebase is a collection of sequences and annotations for over 120 million proteins across all branches of life. Detailed annotations extracted from the literature by expert curators have been collected for over half a million of these proteins. These annotations are supplemented by annotations provided by rule based automated systems, and those imported from other resources. In this article we describe significant updates that we have made over the last 2 years to the resource. We have greatly expanded the number of Reference Proteomes that we provide and in particular we have focussed on improving the number of viral Reference Proteomes. The UniProt website has been augmented with new data visualizations for the subcellular localization of proteins as well as their structure and interactions. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.
Highlights
The proteins expressed in a cell at any moment of time determine its function, its topology, how it reacts to changes in environment and its longevity and well-being
The UniProt Knowledgebase (UniProtKB) combines reviewed UniProtKB/Swiss-Prot entries, to which data have been added by our expert biocuration team, with the unreviewed UniProtKB/TrEMBL entries which are annotated by automated systems including our rulebased systems
We provide the UniRef databases that cluster sequence sets at various levels of sequence identity and the UniProt Archive (UniParc) that delivers a complete set of known sequences, including historical obsolete sequence
Summary
The proteins expressed in a cell at any moment of time determine its function, its topology, how it reacts to changes in environment and its longevity and well-being. It is important to ensure we have a broad enough collection of annotated proteins in UniProtKB/Swiss-Prot to add value to new entries as the taxonomic range of fully sequenced proteomes continues to expand. Every piece of knowledge we capture is associated with evidences (see https://www.uniprot.org/help/evidences for further details) to indicate the source of information and we have added a CAUTION comment to the METTL14 entry to both provide some background and inform users that the initially reported methyltransferase activity is an unsafe observation (Figure 3).
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