Abstract
Alpha-fetoprotein (AFP) is a protein encoded by the AFP gene and normally produced by the fetus. The purpose of this study is to investigate the efficacy of lobaplatin in combination with 5-fluorouracil (5-FU) and doxorubicin on AFP and treatment of primary carcinoma of the liver by transhepatic arterial chemotherapy and embolization (TACE). Patients with primary carcinoma of the liver who took the TACE for treatment were enrolled in this study and divided randomly into the research group and the control group. Patients in the research group adopted the TACE in combination with lobaplatin, while those in the control group took cisplatin instead in combination with TACE. We compared the baseline data, hepatic indicators before treatment and after 1 month of treatment, efficacy and the incidence rates of adverse events after TACE between two groups. Differences in the baseline data, including Child-pugh grade, type of liver cirrhosis, KPS scores and AFP showed no statistical significance (P >0.05). Before the treatment, we identified no significant differences in the comparison of ALT, AST, TBiL and ALB between two groups (P >0.05), while significant differences emerged after treatment (P <0.05). Also, efficacy comparison revealed the significant difference between the two groups (P <0.05). After TACE, patients in the research group reported 1 case of nausea, 1 of vomiting and 1 of necrotic absorption fever, and those in the control group reported 3 cases of nausea, 5 of vomiting and 4 of necrotic absorption fever, with a significant difference in comparison of the incidence rates (P <0.05). TACE is a promising strategy for the treatment of primary carcinoma of the liver, while lobaplatin, as the 3rd generation of anti-tumor platinum-based drugs, is less toxic than cisplatin, but excels in efficacy.
Highlights
Alpha-fetoprotein or alfa fetal protein (AFP) is a protein encoded by the AFP gene and normally produced by the fetus
The purpose of this study is to investigate the efficacy of lobaplatin in combination with 5-fluorouracil (5-FU) and doxorubicin on AFP and treatment of primary carcinoma of the liver by transhepatic arterial chemotherapy and embolization (TACE)
We identified no significant differences in the comparison of ALT, AST, TBiL and ALB between two groups (P >0.05), while significant differences emerged after treatment (P
Summary
Alpha-fetoprotein or alfa fetal protein (AFP) is a protein encoded by the AFP gene and normally produced by the fetus. High levels of AFP in the blood (greater than 500 ng / mL) may be a sign of liver tumors. High levels of AFP may mean other cancers, including Hodgkin's disease, lymphoma, and renal cell carcinoma [1, 2]. Primary carcinoma liver is the most common malignancy in China. According to the latest survey report, the annual mortality rate of patients with primary carcinoma of the liver in China has attained 20.37/100,000, occupying the second place in malignancy-led death, only secondary to the lung cancer in the urban region, and gastric cancer in the rural region [3, 4]. Surgical resection is preferred in the treatment of liver cancer, but only suitable for the patients in the good status of heart and lung functions, limited range of tumor and with no metastasis, instead of all patients
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