Abstract
The regulation of immunoglobulin synthesis by peripheral blood mononuclear cells in vitro was studied in asymptomatic healthy hepatitis B virus (HBV) carriers, patients with chronic active hepatitis B, and control subjects who had circulating antibody to the hepatitis B surface antigen (anti-HBs). Specific helper and suppressor T-cell function were assessed by measurement of pokeweed mitogen (PWM)-stimulated IgG and IgM synthesis in cocultures of lymphocyte subpopulations from HBV-infected patients and controls. Using this assay system, there was no difference in IgG and IgM synthesis by unfractionated PBMCs from the three groups. Also, no differences in suppressor and helper T-cell functions were noted. Thus, immunoregulation of PWM-stimulated IgG and IgM synthesis by lymphocyte subpopulations did not distinguish between chronic HBV-infected patients and controls with circulating anti-HBs.
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