Abstract

The enzyme development start-up Arzeda has landed a 3-year partnership with the consumer goods giant Unilever to develop enzymes for household cleaning applications. Many dish detergents and hard-surface cleaners already use enzymes, which can break down soils, oils, and grime and boost the performance of other ingredients. Enzymes (such as the hydrolase shown), along with live microbes and advanced surfactants, are central to Unilever’s $1.2 billion plan to shift to 100% biobased ingredients in its cleaning products by 2030. Neil Parry, head of biotechnology development at Unilever, says the firm has the opportunity with Arzeda to look beyond the capacities of natural enzymes and into new kinds of enzyme-catalyzed cleaning chemistry. “Although detergents have been around for a long time with enzymes in them, the enzyme classes are quite limited,” he says, “and we believe there’s so many more enzyme classes that can get performance.” Arzeda combines physics-based protein design

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