Abstract
729 Background: At the Antoine Lacassagne center, in Nice, France, between 1977 and 2001, 3336 unilateral breast cancers (UBC) and 298 bilateral breast cancers (BBC) were treated by surgery. This study was leaded to evaluate prognostic of UBC and BBC. Methods: BBC were divided in two groups: synchronous bilateral breast cancers (SBBC) is defined by cancer in each breast either simultaneously or within a 6 months interval and non-synchronous bilateral breast cancer (NSBBC) is defined by controlateral breast cancer over 6 months after the first cancer. Aim of this study is to compare UBC with BBC population and to compare the 103 SBBC with the 195 NSBBC. Results: Comparison of prognosis features of UBC and BBC population: there was no difference regarding median age, menopausal status, tumor size, histological nodal invasion and in situ carcinoma's presence. Nevertheless, we noticed more histological SBR grade III (p=0.055) and more estrogen receptor negative (p=0.02) in UBC group. Therapeutic patterns, as conservative surgery, radiotherapy and adjuvant chemotherapy, were equally distributed between these two populations. No significant difference was noticed regarding overall survival. Comparison of SBBC and NSBBC: SBBC population was older (p=0.001) and presented more histological nodes involvement (52 % vs 26 %; p=0.001) receiving thus more frequently adjuvant hormonotherapy (p=0.001) and chemotherapy (p=0,04). There was no difference in term of tumor size, histological grade, histological type, in situ carcinoma's presence, estrogen and progesterone receptors. The NSBBC population had a better overall survival than the SBBC ones (p=0.007). Conclusions: BBC have the same features and the same outcomes than UBC. They do not require more aggressive treatment. SBBC have a poorer prognosis than NSBBC due to a more frequent axillary nodes involvement. As patients were older, they received more often adjuvant hormonotherapy. No significant financial relationships to disclose.
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