Unilateral uveitis induced by a nonionic iodinated contrast agent

Abstract

Purpose To report recurrent unilateral uveitis after computed tomography (CT) enhanced by the contrast agent iopamidol. Design Observational case report. Methods A 44-year-old man with a history of mixed-cellularity Hodgkin lymphoma, Stage I B (axillar, infraclavicular, subpectoral lymphomas) was under remission after chemotherapy and radiotherapy. The contrast-enhanced CT scans performed every 3 months were within hours followed by a marked unilateral anterior uveitis, vitritis, and retinal bleedings. Symptoms resolved with topical corticosteroid treatment within a week. Results We observed recurrent unilateral uveitis after intravenously application of 150 ml of iopamidol for contrast-enhanced CT scans in a patient with lymphoma in remission. Conclusions Iopamidol may induce uveitis under certain circumstances. We suggest a coincidence of immunologic mechanisms with predisposing discrete vascular radiation damage.