Abstract
Chronic UUO leads to progressive renal tubular atrophy and intersitital fibrosis that may be aggravated by production of reactive oxygen species(ROS). Obstructive nephropathy is frequently associated with chronic sodium wasting and consequent SD. Tissue damage by ROS is attenuated by AOE, including catalase (CAT), manganese superoxide dismutase (MnSOD), copper-zinc SOD (CuZnSOD), glutathione peroxidase (GPx) and glutathione-S-transferase(GST). To investigate the response of renal AOE to SD and UUO, adult male Sprague-Dawley rats were placed on normal sodium (NS)(16.22 mmol/kg/d) or SD(4.75 mmol/kg/d) diets and subjected to UUO or sham operation. Obstructed(UUO), intact opposite (IO), and sham kidneys were harvested after 4 d, the AOE activites measured in homogenates and expressed normalized to protein content. Results (mean± standard deviation, * designates p<0.05 vs NS, # designates p<0.05 vs Sham same Na): Table
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