Abstract
Abstract—Modifications of some membranal enzymatic activities in rabbit brain edema induced by cold injury were studied. The edema was characterized by the tissue H2O content and the K+/Na+ ratio. Comparison of the respiratory rate of isolated mitochondria in the state 3 and 4 and the ADP/O ratio suggested an alteration in the ATP synthesis mechanism. The oligomycin sensitive ATPase activity was severely reduced in mitochondria isolated from edematous cells.The alteration of the ouabain sensitive Na+‐K+‐ATPase was first qualitative in the sense where the response of the ATPase to the K+/Na+ ratio was modified. A loss of the total activity was then observed. Intravenous injection of CDP choline induced a regression of the edema, a restoration of the sensitivity of the mitochondrial ATPase towards oligomycin and a restoration of the sensitivity of the Na+‐K+‐ATPase to the K+/Na+ ratio. These results suggest that the reversible damages of the cells induced by cold injury were due to a disorder at the protein‐lipid interaction level.
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