Abstract
This paper describes a novel natural extracellular matrix-derived scaffold composite prepared through a coordination reaction between small intestinal submucosa (SIS) and strontium (Sr) ions. The physicochemical and biological properties of the Sr/SIS composite scaffold were investigated. The Sr/SIS complex had a porous structure and a uniform distribution of Sr2+. The coordination bond of Sr-SIS provides the Sr/SIS scaffolds with improved mechanical properties and sustained Sr2+ release.Controlled release of Sr2+ enhanced cell proliferation and osteogenic differentiation. The 1.5 wt% Sr/SIS scaffold had the best osteogenesis effect among the experimental groups, indicating its potential as a biomaterial for bone tissue engineering.
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