Uniform porous and functionally graded porous titanium fabricated via space holder technique with spark plasma sintering for biomedical applications

Abstract

Porous materials with low stiffness and high strength are sought as implant materials to prevent stress shielding and fracture during in vivo use. This study proposes a powder metallurgy-based space holder technique to fabricate porous titanium with mechanical performance suitable for implant materials. Mixed powders of titanium and sodium chloride were sintered at low temperature using spark plasma sintering, and then the sodium chloride was dissolved in water. As a result, uniform porous titanium (UP-Ti) with a wide range of microstructures: porosity from 26% to 80% and average pore size from 75 μm to 475 μm was successfully fabricated. Also, functionally graded porous titanium (FGP-Ti) was successfully fabricated, in which porous titanium with high porosity and dense titanium were placed at the inside and surface, respectively. The stiffness of UP-Ti was comparable to that of natural bones, but its strength was lower than that of natural bones, which would be insufficient for use as an implant. In contrast, the mechanical performance of FGP-Ti was improved, compared with UP-Ti with the porosity comparable to the average porosity of FGP-Ti: its strength was higher than that of natural bones and its stiffness was comparable to that of natural bones. These results imply that porous titanium, especially functionally graded porous titanium, is a candidate metal for implants used to replace heavily loaded natural bone.