Abstract
Recent studies using the chick oviduct, a tissue in which progesterone induces synthesis of the protein avidin, have led us to formulate the following sequence of events in progesterone action: steroid permeation of the cell membrane, binding of progesterone to a specific cytoplasmic receptor, transfer of this steroid-receptor complex to the nucleus, binding of the steroid-receptor complex to specific “acceptor sites” on the nuclear chromatin, synthesis of new RNA specific in composition, and synthesis of avidin. These results are discussed in light of evolving experimental information which can now allow us to consider this sequence of events as applicable to the mechanism of action of all steroid hormones.
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