Abstract
Chromatographic batch and simulated moving-bed (SMB) processes where products are collected in less than 100% purity, or part of the effluent is discarded as waste, were analyzed. The Unified Design method was used to visualize the regions of feasible operating parameters under ideal and non-ideal conditions. Binary separations with linear and Langmuir isotherms were considered. The feasible regions of batch chromatography and the classical four-zone SMB are identical for partial separations under ideal conditions. For Langmuir isotherms, the feasible region of an ideal batch column is an excellent approximation for an efficient SMB process when purity constraints are low. Chromatographic processes with waste fractions are represented by two operating points on the Unified Design operating parameter plane. In contrast to batch chromatography, introducing an additional waste stream to an SMB process was found to not improve its performance.
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