Abstract
We report an observation of a good prognosis ungual melanoma showed up 10 years after the onset of a generalized vitiligo. It’s a 66ans years old male, with a history of a rapidly progressing vulgar vitiligo showed up 10 years earlier. The patient has been referred to us for the management of a nail melanoma, retained on clinical and histological data, with a vitiligo extended to 70% Body Surface Area. The assessment of locoregional and distant extension was without abnormalities. Several authors have reported the association of vitiligo and other autoimmune disorders, non-melanoma skin cancers, or as part of a particular syndrome. The association of ungueal melanoma and generalized vitiligo was rarely reported in literature. Across this observation, we illustrate that The association of cutaneous melanoma and vitiligo is not rare and may be a factor of good prognosis.
Highlights
Vitiligo is an autoimmune skin disease which is manifested by achromic patches, due to destruction of melanocytes
We report through this observation a case of a good prognosis ungual melanoma showed up 10 years after the onset of a generalized vitiligo
It turned out that the occurrence of melanoma in patient with vitiligo was more frequent than general population [2]
Summary
Vitiligo is an autoimmune skin disease which is manifested by achromic patches, due to destruction of melanocytes. We report through this observation a case of a good prognosis ungual melanoma showed up 10 years after the onset of a generalized vitiligo. Clinical examination had found a conscious patient, well oriented in time and space, with a vitiligo extended to 70% Body Surface Area (Fig. 2). Dermatological examination identified a dark crust in the outer portion of the right thumbnail and in the lateral nail fold associated with paronychia, without any transit lesions, no palpable lymphadenopathy was apparent (Fig. 3). Dermoscopy has showed crusts and scals with the destruction of the lateral nail fold, with lack of the chaos aspect and no atypical vascularization (Fig. 4). The excision of the tumor was performed with margins of 2 cm
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