Abstract
Proteins, the working machineries inside a cell, are tightly regulated from birth through maturation to death. ClpXP is an ATP dependent protease that is involved in protein quality control and regulation. ClpX is a ring-shaped ATPase that recognizes, denatures and translocates target substrates into ClpP. ClpP is a barrel shaped protease that degrades polypeptide substrates. Despite extensive biochemical studies over the last two decades, much remains unknown about the molecular mechanism of ClpXP. We will visualize the whole process of substrate recognition, denaturation, translocation, and degradation using multicolor single-molecule FRET. This single-molecule study will reveal the mechanism of degradation and product release by ClpXP.
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