Unexpectedly superior efficiency of chloride-directed double Suzuki–Miyaura cross-coupling reactions to bromide-directed reactions for the synthesis of sterically hindered 2,7-diaryl fluorenes

Abstract

Sterically hindered 2,7-diaryl fluorenes have been efficiently synthesized via double Suzuki–Miyaura cross-coupling reactions of challenging 2,7-dichlorofluorene with multiple di-ortho-substituted arylboronic acids using the NHC–Pd catalyst INPd.