Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males.

Hiroki Kurahashi,Beverly S Emanuel

doi:10.1038/ng1001-139

Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males.

Hiroki Kurahashi, Beverly S Emanuel

https://doi.org/10.1038/ng1001-139

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Journal: Nature Genetics	Publication Date: Oct 1, 2001
Citations: 75

Affiliation: Osaka University, Children's Hospital of Philadelphia, University of Pennsylvania

#Translocations In Sperm #Chromosomal Breakage Syndromes + Show 8 more

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Abstract

Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

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