Abstract

Cephalosporanic acid sulphones react with DCC to give a novel 4-spiroazetidinyl-Δ 2 -cephem structure with high stereoselectivity. The reaction, though general for cephem-4-carboxylic acids, is deeply affected by oxidation at sulphur; an external base was required for the 1-sulphide, and stereoselectivity gas lost with the 1α-sulphoxide

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