Abstract
Malignant melanoma is the most aggressive skin cancer. A majority of cancer-associated deaths are due to the invasion of cancer cells to distant tissues. Thus, it is of great importance to understand the mechanisms of metastatic spread. A potential marker for this is BRN2, encoded by the POU3F2 gene, that interacts with SOX transcription factors (Cook and Sturm, 2008; Malik et al., 2018). While some studies consider BRN2 as a positive regulator of microphthalmia-associated transcription factor (MITF), which favors proliferation (Goodall et al., 2004a; Wellbrock et al., 2008), other studies propose a dual function for BRN2 in both tumor proliferation and invasion, which could be controlled via the upregulation or downregulation of MITF, respectively (Simmons et al., 2017; Wellbrock and Arozarena, 2015).
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