Abstract
Summary Graded doses of N-ethyl-N-nitrosourea (NEU) were applied to populations of algal cells pre-cultivated always under standardized conditions. They were found to differ significantly in their physiological and genetical responses to the same doses of the mutagen. Curves connecting effects of equal NEU-doses (concentrations at concentration-dosing and multiples of concentration and time of action at time-dosing) assigned as isodoses or doses needed for inducing the same effects, say isoeffects, had a signiticantly different course for each population. These curves seem to be suitable for demonstration of such differences. Significant influence of different states of cell populations (degree of synchrony, distribution of physiological conditions in single cells, etc.), which were prepared under standardized conditions before the treatment by the mutagen, upon the resulting effects of mutagenesis, may be an explanation.
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