Abstract
Objective To further the understanding of the mechanism behind myoma necrosis and uterus survival after uterine artery occlusion. Method Myomal and myometrial gene transcription and protein expression of tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor type 1 (PAI-1) were investigated in 30 uteri. Results Compared with myometrial expression, myomal expression was less for uPA mRNA (1.34% ± 2.18% vs 2.84% ± 2.97%; P < 0.05) and greater for PAI-1 mRNA (2.67% ± 1.82% vs 1.27% ± 1.99%; P < 0.05), but the difference in tPA mRNA expression was not significant. Accordingly, compared with myometrial expression, myomal expression was less for the uPA protein ( P < 0.05) and greater for the PAI-1 protein ( P < 0.05), but the difference in tPA protein was not significant. Conclusion The PA/PAI system was found to be expressed differently in myomas and the myometrium, which may play a role in uterus survival and myoma necrosis after uterine artery occlusion.
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