Unequal partitioning of AMPA and NMDA conductances leads to robust temporal order sensitivity

Abstract

Event Abstract Back to Event Unequal partitioning of AMPA and NMDA conductances leads to robust temporal order sensitivity NMDA and AMPA receptors coexist at most glutamatergic synapses in the CNS, and are frequently described as having a synergistic interaction: AMPA channels provide the major depolarization needed to relieve NMDA channels of their voltage-dependent Mg2+ block, which can lead unde certain conditions to highly nonlinear regenerative events such as NMDA spikes. With compartmental modeling, we systematically studied the conditions required to achieve two-input summation that is at once (1) strongly superlinear (i.e. "synergistic"), (2) temporal order-dependent (i.e. "causal"), and (3) stable despite fluctuations in synaptic parameters (i.e. "robust"). We found that all three desirable properties can be simultaneously achieved, but only with (1) an unequal allocation of NMDA and AMPA conductances between the two input pathways, and (2) fast-spiking voltage-dependent sodium channels in the dendritic membrane. Our results could serve as a basis for understanding time-dependent contextual modulation effects. Conference: Computational and systems neuroscience 2009, Salt Lake City, UT, United States, 26 Feb - 3 Mar, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: (2009). Unequal partitioning of AMPA and NMDA conductances leads to robust temporal order sensitivity. Front. Syst. Neurosci. Conference Abstract: Computational and systems neuroscience 2009. doi: 10.3389/conf.neuro.06.2009.03.235 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Feb 2009; Published Online: 03 Feb 2009. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Google Google Scholar PubMed Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.