Undifferentiated Carcinoma of the Pancreas, an Atypical Case with Osteoclast-like Giant Cells

Abstract

Undifferentiated osteoclast-type giant cell carcinomas of the pancreas are extremely rare, occurring in less than 1% of neoplastic lesions at the pancreatic level. We present the case of a 54-year-old woman with a family history of a mother who died due to chronic abdominal pain at an early age, who presented with pain and jaundice. 54-year-old female, presenting with diffuse epigastric abdominal pain, of low to moderate intensity, progressive since 2015, managed symptomatically such as gastritis for 6 months until presenting painless jaundice, being diagnosed in our hospital by computed tomography and endoscopy as a mucinous cystic lesion in the common bile duct, being operated in 2016 with a histopathological report of undifferentiated carcinoma of the pancreas of osteoclast-type giant cells, receiving 6 cycles of gemcitabine, with subsequent detection of a solid lesion of 3 cm towards the head of the pancreas, intervened again in 2017, performing a pyloric-preserving pancreaticoduodenectomy.