Abstract
Undifferentiated carcinoma of pancreas with osteoclastic giant cells is a rare tumor. The prognosis is slightly better than usual anaplastic carcinoma. It is said to have an epithelial origin. We present a case of 61-year-old female who presented with features of cholangitis and on evaluation found to have pancreatic mass. Pancreatic intraepithelial neoplasia was also present in our case, which is a feature less commonly noted in published literature.
Highlights
Undifferentiated carcinoma is a malignant neoplasm in which significant portion of the tumor does not show a definitive direction of differentiation.[1]
Undifferentiated carcinoma with osteoclastic giant cells of the pancreas (UC- OGC) is a distinctive tumor type in the pancreas. It is regarded as a variant of sarcomatoid carcinoma with striking chemotaxis of osteoclastic giant cells
In a study by Luchini et al it was purported that UC-OGC’s are variants of pancreatic ductal carcinoma (PDC) due to the presence of shared mutations in KRAS and other critical tumor suppressor genes commonly associated with PDC (TP53, CDKN2A and SMAD4).[10]
Summary
Undifferentiated carcinoma of pancreas with osteoclastic giant cells is a rare tumor. The prognosis is slightly better than usual anaplastic carcinoma. It is said to have an epithelial origin. We present a case of 61-year-old female who presented with features of cholangitis and on evaluation found to have pancreatic mass. Pancreatic intraepithelial neoplasia was present in our case, which is a feature less commonly noted in published literature.
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