Abstract
Weight variability has known as a risk factor for cardiovascular events and mortality. However, its effect on end-stage renal disease (ESRD) development remains controversial. We investigated the relationship between weight change and ESRD risk. Overall, 97,029 patients with DM aged >20 years were selected from the Korean National Health Screening Program 2009–2012. Weight change was defined as differences in body weight from the index year to 2 years later. Newly diagnosed ESRD was observed until 2017 end. Over a 5.1-year median follow-up period, ESRD was newly diagnosed in 7932 (4.81%) DM patients. BMI < 18.5 kg/m2 and waist circumferences <85/80 and >100/95 cm were ESRD risk factors. ESRD risk increased with increasing weight change; ≥10% weight loss (hazard ratio [HR], 1.247) followed by ≥10% weight gain (1.247) was associated with a higher HR than ≤5% weight change after adjusting for several confounding factors. The association between weight change and ESRD risk in a subgroup analysis was significantly stronger in patients aged <65 years, without proteinuria, with BMI ≥ 25, with DM duration <5 years, and prescribed less than 3 classes of DM medication. Underweight patients showed higher ESRD risks than overweight patients. Weight loss >10% was associated with the fastest decline in renal function.
Highlights
Despite the observational studies that reported positive associations between obesity and chronic kidney disease (CKD) or ESRD, there is not much evidence to prove that obesity is an independent risk factor for end-stage renal disease (ESRD) [1,2,3,4,5]
The distribution of the population according to body mass index (BMI) change was BMI < 25/
Showed the highest risk for incident ESRD; (4) this association was greater in magnitude in patients aged
Summary
NHIS which includes all data claims and the Medical Aid programs. The Korean NHIS database database is representative of the entire population of the Republic of. The details is representative of the entire population of the Republic of Korea, and the details of of this database have beendescribed describedpreviously. Corporation everyevery year or every every other year, depending on their occupation. The database includes sociodemoother year, depending on their occupation. The database includes sociodemographic data graphic data and all medical expenses inpatientservices, and outpatient services, pharmacy and all medical expenses for inpatient andfor outpatient pharmacy dispensing claims dispensing claims and death information. Anonymous data is disclosed in the National and death information. Anonymous data is disclosed in the National Health Insurance.
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