Abstract
Cacti fruits are known to possess antioxidant and antiproliferative activities among other health benefits. The following paper evaluated the antioxidant capacity and bioactivity of five clarified juices from different cacti fruits (Stenocereus spp., Opuntia spp. and M. geomettizans) on four cancer cell lines as well as one normal cell line. Their antioxidant compositions were measured by three different protocols. Their phenolic compositions were quantified through high performance liquid chromatography and the percentages of cell proliferation of fibroblasts as well as breast, prostate, colorectal, and liver cancer cell lines were evaluated though in vitro assays. The results were further processed by principal component analysis. The clarified juice from M. geomettizans fruit showed the highest concentration of total phenolic compounds and induced cell death in liver and colorectal cancer cells lines as well as fibroblasts. The clarified juice extracted from yellow Opuntia ficus-indica fruit displayed antioxidant activity as well as a selective cytotoxic effect on a liver cancer cell line with no toxic effect on fibroblasts. In conclusion, the work supplies evidence on the antioxidant and antiproliferative activities that cacti juices possess, presenting potential as cancer cell proliferation preventing agents.
Highlights
According to a recent report by the World Health Organization (WHO), cancer is a collection of diseases that is the second leading cause of mortality worldwide
We studied the in vitro bioactive potential of in-house extracted between antioxidant capacity and antiproliferative properties of Mexican cactus fruit juices from different cacti fruits against cancer cell lines and a normal cell line, with the juices
The results presented in this paper prove the antioxidant properties of five Mexican native cactus fruits by ABTS, DPPH, Ferric Reducing Antioxidant Power (FRAP) and Folin–Ciocalteu methods, as well as the in vitro cell cytotoxicity on cell lines
Summary
According to a recent report by the World Health Organization (WHO), cancer is a collection of diseases that is the second leading cause of mortality worldwide. The uncontrolled stage of this collection of illnesses is called metastasis and is a major cause of death. Cancer disease cause of death globally accounted for an estimated 9.6 million deaths in 2018, which could have increased by 50% to 15 million by 2020 [1]. Liver cancer alone caused 782,000 deaths [1]. Cactaceae plants are a group of uncommon species worldwide that grow in arid areas. Cacti fruits are highly valued in the region for their chemical composition which grants them their distinctive organoleptic properties such as color and taste [4]. Few studies detail the chemical characterization of cacti fruits, and their bioactive properties
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