Abstract
Nonvalvular atrial fibrillation (AF) is the most widespread cardiac arrhythmia of clinical significance worldwide, and its prevalence is increasing.1,2 Atrial fibrillation is a substantial health problem because it significantly increases the risk of thromboembolic events, particularly that of stroke.3 Moreover, strokes associated with AF are more severe, involve larger vascular territories, and cause more morbidity and death than do strokes from other causes.4
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