Understanding thermolabile protecting groups for nucleic acid-based drugs

Abstract

Understanding thermolabile protecting groups for necleic acid-based drugs Serge L. Beaucage investigates thermolabile protecting groups for the amine functions of purine and pyrimidine deoxyribonucleosides for the development and implementation of synthetic DNA sequences as nucleic acid-based drugs. The high demand for nucleic acid-based drugs, earmarked for treating human diseases, requires improved chemical methods for rapid and efficient chemical synthesis of synthetic DNA and/or RNA sequences with protecting groups before being processed and manufactured in sufficient quantity and purity for clinical indications. Given that the purity of synthetic DNA/RNA sequences is of the utmost importance for their intended purposes, sustained research efforts have been made.