Understanding the role of NOS-3 in ventilator-induced lung injury: don't take NO for an answer

Abstract

although nitric oxide synthases (NOSs) were first described in 1989 ([12][1]), these complex enzymes are still not fully understood, and their role in human lung disease remains unclear. Three NOS isoforms have been described in humans: neuronal or nNOS (NOS-1), inducible or iNOS (NOS-2), and