Understanding the Prefrontal Cortex

Abstract

Abstract The primate prefrontal cortex sits at the top of the sensory, motor, and outcome processing hierarchies of the neocortex. It transforms sensory inputs into motor outputs, determining the response that is appropriate given the current context and desired outcome. This transformation involves conditional rules. The dorsal prefrontal cortex supports the learning of behavioural sequences, where the next action is conditional on the previous one. The ventral prefrontal cortex supports associations between objects, where the choice of one object is conditional on the presence of another object. However, because hierarchical processing supports the extraction of abstract representations, the primate prefrontal cortex is able to represent conditional rules that are abstract, meaning that they apply irrespective of the specific inputs. The selective advantage is that by learning these rules, primates can solve new problems rapidly when they have the same conditional logic as prior problems. The human prefrontal cortex has the same fundamental organization as in other primates. The dorsal prefrontal cortex supports the understanding of sequences and the ventral prefrontal cortex supports the ability to learn semantic associations. Thus the human prefrontal cortex has co-opted and elaborated mechanisms that were present in ancestral primates. These mechanisms can be used for new ends. For example, words have been associated with objects so as to communicate with others. This means that to understand human intelligence it is necessary to take into account the fact that the abstract rules are transmitted verbally from one generation to another.