UNDERSTANDING THE METABOLIC RISK FACTOR CLUSTERING: ITS ASSOCIATION WITH OXIDATIVE STRESS AND DIABETES MELLITUS

Abstract

Metabolic risk factor clustering is the key concept of Insulin resistance and Diabetes Mellitus. Oxidative stress plays an important role in the progression of clustering in the cascade pattern. According to W.H.O. Type 2 Diabetes Mellitus has already reached epidemic proportions currently affecting over 422 million people worldwide and one of the four leading non-communicable diseases highlighted in the targets of the WHO Global Monitoring Framework (2019-20). Oxidative stress from oxidative metabolism had been reported to cause base damage, as well as break strand in genetic level .oxidative stress is thought to be involved in the development of atherosclerosis (CVD) and had been cited to be of etiological importance in cardiovascular diseases. The present study highlights the various traits of metabolic clustering and its association with reactive oxygen species (ROS).