Abstract
Background and aims: Merkel cell polyomavirus (MCPyV) causes an aggressive human skin cancer, Merkel cell carcinoma (MCC), through expression of two viral oncoproteins: small T (ST) and a truncated form of large T (t-LT). In vitro cell transformation and migration assays have shown that ST is sufficient to induce anchorage independent growth as well as a cell migratory phenotype in human skin fibroblasts (HFFs), the potential host cell of MCPyV infection. In this study we aim to identify the cellular mechanism that are perturbed by ST to drive transformation and migration.
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