Abstract
A deeper understanding of the electrochemical hydration of the alkynes may promote the development of such reactions. By using 4-tert-butylphenylacetylene as the model substrate, the mechanism of the electro-hydration of acetylenes is investigated through the designed experiments and theoretical calculations. It is suggested that the reaction may follow two possible radical processes simultaneously. The major is a cascade pathway including an oxidative halogenation followed by an electrochemical stepwise-dehalogenation, and the minor is the direct hydration of the substrate on the electrode surface. The inference is further confirmed by the corresponding thermodynamic calculations. This mechanistic study provides a theoretical basis for the future design and synthesis of various functionalized aryl ketones from the arylacetylenes by the electrochemistry strategy.
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