Abstract
Ryanodine (Ryd) is a poisonous plant alkaloid that specifically binds ryanodine receptors (RyRs) with distinguishable affinities. Some of its binding modes can sharply enhance the open probabilities, thus helping to demonstrate the vital roles of RyRs as a family of intracellular calcium release channels in skeletal, cardiac and neuronal cells. Although electrophysiology and mutagenesis experiments have shed some light on the binding mechanism of Ryd to RyRs, a full atomistic insight of the receptor-ligand recognition process is still lacking.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
