Abstract
Plasma membrane (PM) is a dynamic barrier which translates the outside signals to the cell. We are interested in how changes in the PM (composition, organization etc) influence cell homeostasis and vice versa. For this purpose we constructed two permanent Chinese Hamster Ovary (CHO KI) cell lines with permanent modifications in the PM lipid composition. The first line (SCD), over expressing Stearoyl CoA desaturase resulted in an increase of monounsaturated fatty acids at the PM phospholipids. The second cell line over expressing both Δ5 and Δ 6 desaturases (Δ 5/ Δ 6-cells), turned into a rise of poly unsaturated fatty acids and lower ratio cholesterol/phospholipids.
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