Abstract
The NIH Common Fund GTEx project is designed to serve as a data and post-mortem tissue resource to the research community. The project is testing the role of genomic variation in altering gene expression across a wide array of tissues in a large number of human post-mortem donors. Both data and tissue samples are available to the research community for additional studies.
Highlights
The publication of the results from the Psychiatric GWAS Consortium showing 108 genetic loci linked to a diagnosis of schizophrenia[1] represents a milestone for psychiatric genetics and presents a challenge
With the Genotype Tissue Expression (GTEx) Project, the NIH Common Fund seeks to bridge the gap between SNPs of unknown function and changes in gene expression in human brain and many other organs and tissues
The goal of the GTEx project is to create a data and tissue resource to serve as a reference set for studies of the genomic basis of disease
Summary
The NIH Common Fund GTEx project is designed to serve as a data and post-mortem tissue resource to the research community. The project is testing the role of genomic variation in altering gene expression across a wide array of tissues in a large number of human post-mortem donors. Both data and tissue samples are available to the research community for additional studies. Other studies have measured gene expression levels in brain (for example, BrainSpan, http://www.brainspan.org/; BrainCloud;[3] http://braincloud.jhmi.edu/), but GTEx is the first project to expand the analysis to a broad array of both brain and non-brain tissues from a large number of individuals.
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