Abstract

Large-scale connectome studies characterize the human brain as a network of complex interactions across different regions, highlighting the well-organized connectivity patterns underlying daily brain activity. In this macroscale connectome view, psychiatric disorders have been conceptualized as manifestations of abnormal wiring or network dysfunction (1) in autism spectrum disorder (ASD), with aberrant functional connections in the so-called social brain network. Accumulating evidence suggests that the functional brain connectome during rest spontaneously fluctuates in time-varying network strength or patterns, which benefits the prompt response to different cognitive states (2).

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